It has been 50 years since scientists first created DNA in a test tube, stitching ordinary chemical ingredients together to make life’s most extraordinary molecule. Until recently, however, even the most sophisticated laboratories could make only small snippets of DNA — an extra gene or two to be inserted into corn plants, for example, to help the plants ward off insects or tolerate drought.
Now researchers are poised to cross a dramatic barrier: the creation of life forms driven by completely artificial DNA.
Scientists in Maryland have already built the world’s first entirely handcrafted chromosome — a large looping strand of DNA made from scratch in a laboratory, containing all the instructions a microbe needs to live and reproduce.
…”We’re heading into an era where people will be writing DNA programs like the early days of computer programming, but who will own these programs?” asked Drew Endy, a scientist at the Massachusetts Institute of Technology.
…Venter has now built the first fully artificial chromosome, a strand of DNA many times longer than anything made by others and laden with all the genetic components a microbe needs to get by.
Details of the process are under wraps until the work is published, probably early next year. But Venter has already shown that he can insert a “natural” chromosome into a cell and bring it to life. If a synthetic chromosome works the same way, as expected, the first living cells with fully artificial genomes could be growing in dishes by the end of 2008.
The plan is to mass-produce a plain genetic platform able to direct the basic functions of life, then attach custom-designed DNA modules that can compel cells to make synthetic fuels or other products.
…”Ultimately synthetic biology means cheaper and widely accessible tools to build bioweapons, virulent pathogens and artificial organisms that could pose grave threats to people and the planet,” concluded a recent report by the Ottawa-based ETC Group, one of dozens of advocacy groups that want a ban on releasing synthetic organisms pending wider societal debate and regulation.
…”The cat is out of the bag,” said Jay Keasling, chief of synthetic biology at the University of California at Berkeley.